Dietary Influences on Clostridium difficile Infections in the Neonatal Pig

dc.contributor.author Warfield, Alexandra Czarina
dc.contributor.majorProfessor Rowe, Eric
dc.date.accessioned 2024-04-29T13:59:48Z
dc.date.available 2024-04-29T13:59:48Z
dc.date.copyright 2024
dc.date.issued 2024-05
dc.description.abstract Clostridium difficile (C. difficile) is a gram-positive, rod-shaped bacterium known for causing gastroenteritis and diarrhea in neonatal piglets. Its ability to form spores increases its odds of survival in the environment (soil, water, and animal gastrointestinal tracts), making it challenging to control. Ribotyping identifies different C. difficile strains, with ribotype 078 being most prevalent in swine. The neonatal piglet microbiome, influenced by the vaginal canal during birth, environment, and milk flora, undergoes dynamic changes postpartum. Formula feeding alters gut flora composition, increasing susceptibility to Clostridium difficile infections (CDIs) compared to suckling piglets. Enteral feeding strategies impact gut maturation and CDI risk, with colostrum-fed piglets showing improved outcomes. Understanding the gut microbiota's role in resisting C. difficile over-colonization is crucial. Increased bacterial diversity correlates with decreased CDI risk. Prevention and treatment strategies, including antibiotics and pre- & probiotics, aim to mitigate CDI severity. Colostrum, particularly hyperimmunized bovine colostrum, shows promise in preventing and treating CDIs in piglets. Further research is needed to explore the efficacy of hyperimmunized bovine colostrum and optimize prevention and treatment strategies to combat C. difficile infections in neonatal piglets effectively. Additionally, research into porcine hyperimmunized colostrum should be investigated to see if species-specific hyperimmunized colostrum may be more beneficial.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/105740
dc.language.iso en_US
dc.rights CC0 1.0 Universal *
dc.rights.holder Alexandra Czarina Warfield
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/ *
dc.subject.disciplines DegreeDisciplines::Life Sciences::Animal Sciences
dc.subject.keywords Clostridium difficile
dc.subject.keywords Hyperimmunized colostrum
dc.subject.keywords Neonatal pigs
dc.subject.keywords Microbiome
dc.subject.keywords Clostridium difficile infections
dc.subject.keywords Dietary
dc.title Dietary Influences on Clostridium difficile Infections in the Neonatal Pig
dc.type Text
dc.type.genre creativecomponent
dspace.entity.type Publication
relation.isDegreeOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
thesis.degree.department Biomedical Sciences
thesis.degree.discipline Biomedical Sciences
thesis.degree.level Masters
thesis.degree.name Master of Science
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