T cell signaling: biochemical and structural characterization of Itk, CypA and HS1.

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2009-01-01
Authors
Xu, Ruo
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Amy H. Andreotti
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Altmetrics
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Biochemistry, Biophysics and Molecular Biology
Abstract

T cell signaling pathway involves complicated intermolecular and intramolecular interactions. Interleukin-2 tyrosine kinase (Itk), cyclophilin A (CypA) and hematopoietic lineage cell-specific protein (HS1) are three key mediators in this pathway. This thesis explores the negative regulation of Itk activity by CypA and the autoinhibitory regulation mechanism by the HS1 protein through biochemical and structural methods.

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Thu Jan 01 00:00:00 UTC 2009