Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

Thumbnail Image
Date
2012-01-01
Authors
Mann, Francis
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Peters, Reuben
Distinguished Professor
Research Projects
Organizational Units
Journal Issue
Is Version Of
Versions
Series
Abstract

The actinomycetes family of bacteria is classically considered a rich source of natural products [1]. It is often suggested that such compounds have been selected by evolution to have biological activity [2]. For example, given the microbial-rich soil environment of the actinomycetes native habitat, their natural products have been suggested to serve in chemical warfare and/or signaling, which has been further connected to their leading role in providing pharmaceutically relevant antibiotic agents [3]. Nevertheless, surprisingly few of these molecules have been definitively assigned specific physiological roles in the native producing bacteria.

Comments

This is a manuscript of an article published as Mann, F.M., Peters, R.J. (2012) “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., 3(8):899-904, doi: 10.1039/C2MD20030A. Posted with permission.

Description
Keywords
Citation
DOI
Copyright
Sun Jan 01 00:00:00 UTC 2012
Collections