Emergence of a Tetracycline-Resistant Campylobacter jejuni Clone Associated with Outbreaks of Ovine Abortion in the United States

dc.contributor.author Plummer, Paul
dc.contributor.author Sahin, Orhan
dc.contributor.author Plummer, Paul
dc.contributor.author Jordan, Dianna
dc.contributor.author Sulaj, Kapllan
dc.contributor.author Pereira, Sonia
dc.contributor.author Zhang, Qijing
dc.contributor.author Robbe-Austerman, Suelee
dc.contributor.author Wang, Liping
dc.contributor.author Yaeger, Michael
dc.contributor.author Hoffman, Lorraine
dc.contributor.author Zhang, Qijing
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-02-17T10:19:56.000
dc.date.accessioned 2020-07-07T05:14:24Z
dc.date.available 2020-07-07T05:14:24Z
dc.date.issued 2008-05-01
dc.description.abstract <p><em>Campylobacter</em> infection is one of the major causes of ovine abortions worldwide. Historically, <em>Campylobacter fetus</em> subsp. <em>fetus</em> was the major cause of<em>Campylobacter</em>-associated abortion in sheep; however, <em>Campylobacter jejuni</em> is increasingly associated with sheep abortions. We examined the species distribution, genotypes, and antimicrobial susceptibilities of abortion-associated<em>Campylobacter</em> isolates obtained from multiple lambing seasons on different farms in Iowa, Idaho, South Dakota, and California. We found that <em>C. jejuni</em> has replaced<em>C. fetus</em> as the predominant <em>Campylobacter</em> species causing sheep abortion in the United States. Most strikingly, the vast majority (66 of 71) of the <em>C. jejuni</em> isolates associated with sheep abortion belong to a single genetic clone, as determined by pulsed-field gel electrophoresis, multilocus sequence typing, and <em>cmp</em> gene (encoding the major outer membrane protein) sequence typing. The in vitro antimicrobial susceptibilities of these isolates to the antibiotics that are routinely used in food animal production were determined using the agar dilution test. All of the 74 isolates were susceptible to tilmicosin, florfenicol, tulathromycin, and enrofloxacin, and 97% were sensitive to tylosin. However, all were resistant to tetracyclines, the only antibiotics currently approved in the United States for the treatment of <em>Campylobacter</em> abortion in sheep. This finding suggests that feeding tetracycline for the prevention of <em>Campylobacter</em> abortions is ineffective and that other antibiotics should be used for the treatment of sheep abortions in the United States. Together, these results indicate that a single tetracycline-resistant <em>C. jejuni</em>clone has emerged as the major cause of <em>Campylobacter</em>-associated sheep abortion in the United States.</p>
dc.description.comments <p>This article is from <em>Journal of Clinical Microbiology</em> 46 (2008): 1663, doi:<a href="http://dx.doi.org/10.1128/JCM.00031-08" target="_blank">10.1128/JCM.00031-08</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/120/
dc.identifier.articleid 1119
dc.identifier.contextkey 7989698
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/120
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92222
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/120/2008_Plummer_EmergenceTetracycline.pdf|||Fri Jan 14 19:10:17 UTC 2022
dc.source.uri 10.1128/JCM.00031-08
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.title Emergence of a Tetracycline-Resistant Campylobacter jejuni Clone Associated with Outbreaks of Ovine Abortion in the United States
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication f16d5130-7036-437d-892d-b4a4072903e7
relation.isAuthorOfPublication 1c6a5dfc-c604-457f-85be-122910db782e
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
File
Original bundle
Now showing 1 - 1 of 1
Name:
2008_Plummer_EmergenceTetracycline.pdf
Size:
811.44 KB
Format:
Adobe Portable Document Format
Description:
Collections