The synthesis of Fumonisin B1 analogs and silicon crosslinking agents

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1992
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Applegate, Jacqueline
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George A. Kraus
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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The Department of Chemistry was founded in 1880.

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1880-present

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Abstract

Fumonisin B[subscript]1 was recently isolated and characterized. This natural product has significant biological importance along with a unique structure. This study was undertaken to explore the synthesis of fumonisin B[subscript]1 analogs and the biological activity of these analogs. The analogs which were synthesized has the essential functionality required for biological activity. Analog I has both the tricarballylic acid moiety and an amine. Analog II and Analog III has the tricarballylic acid side chain, an amine and the 1,3-diol moiety;Silicon heterocycles are interesting compounds with industrial applications in the area of silicon polymer chemistry. Various strategies toward the synthesis of cyclic silylamides and cyclic silyl enol ethers were investigated.

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Wed Jan 01 00:00:00 UTC 1992