Genome-Wide Association Analyses of Biological Responses to Heat Stress in Pigs

dc.contributor.author Kim, Kwan-Suk
dc.contributor.author Kim, Eui-Soo
dc.contributor.author Seibert, Jacob
dc.contributor.author Rothschild, Max
dc.contributor.author Keating, Aileen
dc.contributor.author Baumgard, Lance
dc.contributor.author Ross, Jason
dc.date 2018-08-25T19:13:12.000
dc.date.accessioned 2020-06-29T23:36:11Z
dc.date.available 2020-06-29T23:36:11Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2015-01-01
dc.description.abstract <p>With genetic selection for rapid, lean tissue accretion, pigs are becoming increasingly sensitive to heat stress (HS) due to their physiological limitations such as the lack of functional sweat glands to effectively dissipate heat. Increased respiration rate and reduced feed intake are immediate and conserved biological responses to HS in pigs and other livestock species. Genetic differences in how animals respond to high ambient temperatures have been previously reported, but genetic factors contributing to the response variability remain ill-defined. In this study, porcine high density single nucleotide polymorphism (SNP) beadchips were used to genotype 236 female pigs who had been exposed to HS conditions, and analyzed to detect chromosomal regions associated with biological responses measured before and after HS, including rectal temperature, respiration rate, feed intake, and body weight loss. We identified significant gene region associations for rectal temperature on SSC12, respiration rate on SSC14 and SSC16, as well as feed efficiency and weight loss on SSC13. Further analyses of these detected regions will likely reveal potential candidate genes and suggest molecular mechanisms contributing to the variability in the biological response of pigs to environmentally-induced hyperthermia.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol661/iss1/92/
dc.identifier.articleid 2138
dc.identifier.contextkey 6761550
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-1343
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol661/iss1/92
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9210
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R3029
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol661/iss1/92/R3029.pdf|||Sat Jan 15 02:29:38 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Bioinformatics
dc.subject.disciplines Computational Biology
dc.subject.disciplines Genomics
dc.subject.keywords ASL R3029
dc.subject.keywords Animal Science
dc.title Genome-Wide Association Analyses of Biological Responses to Heat Stress in Pigs
dc.type article
dc.type.genre swine
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isAuthorOfPublication abe31007-187a-4174-864e-6871e3f9a0d7
relation.isJournalIssueOfPublication 6758d906-7d2a-4198-98dc-f5f25ab96561
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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