Conformational snapshots of Tec kinases during signaling

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2009-03-01
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Joseph, Raji
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Andreotti, Amy
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The control of cellular signaling cascades is of utmost importance in regulating the immune response. Exquisitely precise protein-protein interactions and chemical modification of substrates by enzymatic catalysis are the fundamental components of the signals that alert immune cells to the presence of a foreign antigen. In particular, the phosphorylation events induced by protein kinase activity must be spatially and temporally regulated by specific interactions to maintain a normal and effective immune response. High resolution structures of many protein kinases along with supporting biochemical data are providing significant insight into the intricate regulatory mechanisms responsible for controlling cellular signaling. The Tec family kinases are immunologically important kinases for which regulatory details are beginning to emerge. This review focuses on bringing together structural insights gained over the years to develop an understanding of how domain interactions both within the Tec kinases and between the Tec kinases and other signaling molecules control immune cell function.

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This is the peer reviewed version of the following article: Joseph, Raji E., and Amy H. Andreotti. "Conformational snapshots of Tec kinases during signaling." Immunological reviews 228, no. 1 (2009): 74-92, which has been published in final form at doi: 10.1111/j.1600-065X.2008.00740.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Thu Jan 01 00:00:00 UTC 2009
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