Preferential Inhibition of Primary Granule Release from Bovine Neutrophils by a Brucella abortus Extract

dc.contributor.author Bertram, Timothy
dc.contributor.author Canning, Peter
dc.contributor.author Roth, James
dc.contributor.author Roth, James
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T04:39:49.000
dc.date.accessioned 2020-07-07T05:15:17Z
dc.date.available 2020-07-07T05:15:17Z
dc.date.issued 1986-04-01
dc.description.abstract <p>A low-molecular-weight Brucella abortus extract (a nucleotidelike material) inhibited zymosan-elicited neutrophil degranulation and trichloroacetic acid-precipitable protein iodination (a measure of myeloperoxidase and 8 20 2 release from neutrophilic leukocytes). Inhibition of neutrophU function was directly related to the concentration of the Brucella extract. The extract preferentially inhibited degranulation of primary (azurophUic or peroxidase positive) granules and had limited inhibition of secondary (specific or peroxidase negative) granule release but did not inhibit opsonized zymosan ingestion. Inhibition of protein iodination closely paralleled that of primary granule release but was unrelated to inhibition of secondary granule release. These results suggest that B. abortus has a component which is capable of inhibiting release of myeloperoxidase by dose-dependent preferential inhibition of primary granule release from bovine neutrophilic leukocytes.</p>
dc.description.comments <p>This article is from <em>Infection and Immunity</em> 52 (1986): 285.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/58/
dc.identifier.articleid 1053
dc.identifier.contextkey 7786113
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/58
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92364
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/58/1986_Roth_PreferentialInhibition.pdf|||Sat Jan 15 01:01:06 UTC 2022
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Preferential Inhibition of Primary Granule Release from Bovine Neutrophils by a Brucella abortus Extract
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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