Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)

dc.contributor.author Dolebo, Asrat Tera
dc.contributor.author Khayatzadeh, Negar
dc.contributor.author Rothschild, Max
dc.contributor.author Melesse, Aberra
dc.contributor.author Wragg, David
dc.contributor.author Rekik, Mourad
dc.contributor.author Haile, Aynalem
dc.contributor.author Rischkowsky, Barbara
dc.contributor.author Rothschild, Max
dc.contributor.author Mwacharo, Joram
dc.contributor.department Animal Science
dc.date 2019-12-02T16:34:53.000
dc.date.accessioned 2020-06-29T23:41:23Z
dc.date.available 2020-06-29T23:41:23Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2019
dc.date.issued 2019-12-01
dc.description.abstract <p>Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanning <em>BMP15</em>, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits included <em>SPOCK1</em> (age at first oestrus), <em>GPR173</em> (mediator of ovarian cyclicity), <em>HB</em>-<em>EGF</em> (signalling early pregnancy success) and <em>SMARCAL1</em> and <em>HMGN3a</em> (regulate gene expression during embryogenesis). The genes involved in male reproduction were <em>FOXJ1</em> (sperm function and successful fertilization) and <em>NME5</em> (spermatogenesis). We also observed genes such as <em>PKD2L2</em>, <em>MAGED1</em> and <em>KDM3B</em>, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control of <em>BMP15</em> while other genes that enhance male and female fertility are essential for reproductive fitness.</p>
dc.description.comments <p>This article is published as Dolebo, Asrat Tera, Negar Khayatzadeh, Aberra Melesse, David Wragg, Mourad Rekik, Aynalem Haile, Barbara Rischkowsky, Max F. Rothschild, and Joram M. Mwacharo. "Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)." <em>Mammalian Genome</em> 30 (2019): 339-352. doi: <a href="http://dx.doi.org/10.1007/s00335-019-09820-5" target="_blank">10.1007/s00335-019-09820-5</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/508/
dc.identifier.articleid 1509
dc.identifier.contextkey 15899200
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/508
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9943
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/508/2019_Rothschild_IdentifyKnown.pdf|||Sat Jan 15 00:42:33 UTC 2022
dc.source.uri 10.1007/s00335-019-09820-5
dc.subject.disciplines Biotechnology
dc.subject.disciplines Ecology and Evolutionary Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Population Biology
dc.subject.disciplines Sheep and Goat Science
dc.title Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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