Clinical outcome of transcervical infusion of a combination of procaine penicillin and gentamicin in late-term pregnant mares

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Date
2021-08-06
Authors
Beachler, Theresa
Papich, Mark
Beachler, Theresa
Andrews, Natalie
Von Dollen, Karen
Ellis, Katelyn
Withowski, Katie
Bailey, C. Scott
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Veterinary Diagnostic and Production Animal Medicine
Abstract

Transcervical intrauterine infusion of antibiotics may more effectively treat pathogens associated with fetal and neonatal disease in pregnant mares than standard systemic routes. The objective of this study was to assess the safety of transcervical antibiotic infusion by characterizing the gestational outcome in 9 healthy pregnant pony mares following a single transcervical infusion of 2.4 million IU of procaine penicillin and 200 mg of gentamicin in a 10mL volume during late gestation. Assessment of fetal-placental health was performed through serial measurement of the combined thickness of the uterus and placenta (CTUP) and fetal heart rate and mares and foals were closely monitored in the periparturient period. Fetal heart rate and CTUP remained unchanged after infusion, with no evidence of fluid accumulation or significant increase at the time-points 24, 48, and 72 hours. All mares foaled without complication 12 to 58 days after antibiotic infusion at a mean gestational age of 322.7 ± 12.7 days. Two out of nine foals displayed signs of mild neonatal maladjustment syndrome that responded to minimal supportive care and all foals survived to weaning without further complications.

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This is a manuscript of an article published as Beachler, Theresa M., Mark G. Papich, Natalie C. Andrews, Karen A. Von Dollen, Katelyn E. Ellis, Katie Withowski, and C. Scott Bailey. "Clinical outcome of transcervical infusion of a combination of procaine penicillin and gentamicin in late-term pregnant mares." Journal of Equine Veterinary Science (2021): 103727. Posted with permission.

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