Probiotic Lactobacillus acidophilus strain NP51® Curtails the Progression of Mycobacterium avium Subspecies paratuberculosis (MAP) Infection in Balb/c mice

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2011-01-01
Authors
Osman, Mohamed
Stabel, Judith
Hostetter, Jesse
Nettleton, Daniel
Beitz, Donald
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Abstract

We evaluated the preventative effects of Lactobacillus acidophilus strain NP51 fed to Balb/c mice infected with a virulent strain of Mycobacterial avium subspecies paratuberculosis (MAP) isolated from a clinical cow at the National Animal Disease Center in Ames, Iowa. Mice were randomized to treatment groups that were fed either viableor heat-killed NP51 and inoculated with either viable- or heat-killed MAP or sterile phosphate-buffered saline. Feeding the NP51 elevated numbers of T lymphocytes in the spleen and increased the concentration of interferongamma (IFN-γ) in the supernatant of splenocytes stimulated in vitro with MAP antigen. Most importantly, feeding the NP51 lowered the number of viable MAP CFU in the livers of infected mice on day 180 of the study. These results suggest that feeding the NP51 to BALB/c mice has potential to prevent the advance of MAP infection in mice.

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