Impairing Existing Declarative Memory in Humans by Disrupting Reconsolidation

dc.contributor.author Chan, Jason
dc.contributor.author LaPaglia, Jessica
dc.contributor.author Chan, Jason
dc.contributor.department Psychology
dc.date 2018-02-15T18:59:46.000
dc.date.accessioned 2020-06-30T06:24:57Z
dc.date.available 2020-06-30T06:24:57Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.embargo 2015-01-23
dc.date.issued 2013-04-01
dc.description.abstract <p>During the past decade, a large body of research has shown that memory traces can become labile upon retrieval and must be restabilized. Critically, interrupting this reconsolidation process can abolish a previously stable memory. Although a large number of studies have demonstrated this reconsolidation associated amnesia in nonhuman animals, the evidence for its occurrence in humans is far less compelling, especially with regard to declarative memory. In fact, reactivating a declarative memory often makes it more robust and less susceptible to subsequent disruptions. Here we show that existing declarative memories can be selectively impaired by using a noninvasive retrieval–relearning technique. In six experiments, we show that this reconsolidation-associated amnesia can be achieved 48 h after formation of the original memory, but only if relearning occurred soon after retrieval. Furthermore, the amnesic effect persists for at least 24 h, cannot be attributed solely to source confusion and is attainable only when relearning targets specific existing memories for impairment. These results demonstrate that human declarative memory can be selectively rewritten during reconsolidation.</p>
dc.description.comments <p>This is a manuscript of an article from Proceedings of the National Academy of Sciences 110 (2013): 9309, doi:<a href="http://dx.doi.org/10.1073/pnas.1218472110" target="_blank">10.1073/pnas.1218472110</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/psychology_pubs/15/
dc.identifier.articleid 1018
dc.identifier.contextkey 6560600
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath psychology_pubs/15
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/57945
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/psychology_pubs/15/2013_Chan_ImparingExisting.pdf|||Fri Jan 14 20:31:15 UTC 2022
dc.source.uri 10.1073/pnas.1218472110
dc.subject.disciplines Cognitive Psychology
dc.subject.keywords Neuroscience Interdisciplinary Program
dc.subject.keywords forgetting
dc.subject.keywords human memory
dc.subject.keywords misinformation effect
dc.subject.keywords testing effect
dc.subject.keywords eyewitness memory
dc.title Impairing Existing Declarative Memory in Humans by Disrupting Reconsolidation
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 6b21bbe1-e5e9-4996-9c20-866944f45210
relation.isOrgUnitOfPublication 796236b3-85a0-4cde-b154-31da9e94ed42
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