Ultrafast excited-state processes in the antiviral agent hypericin

Supplemental Files
Date
1993-04-01
Authors
Gai, F.
Fehr, Michael
Petrich, Jacob
Petrich, Jacob
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Chemistry
Organizational Unit
Journal Issue
Series
Department
Chemistry
Abstract

Hypericin (Figure 1) has been shown by Lavieet al. toinactivate mature and properly assembled retroviruses, notably human immunodeficiency virus (HIV).' Recently Kraus, Carpenter, and co-workers demonstrated the antiretroviral activity of hypericin against equine infectious anemia virus (EIAV), a lentivirus closely related to HIV, and have determined that light is required for activity.2 The requirement of light leads to the fundamental questions, what is the mechanism of action of hypericin and what is the role of light?

Comments

Reprinted (adapted) with permission from Journal of the American Chemical Society 115 (1993): 3384, doi: 10.1021/ja00061a069. Copyright 1993 American Chemical Society.

Description
Keywords
Citation
DOI
Collections