Reaction of Fumonisin with Glucose Prevents Promotion of Hepatocarcinogenesis in Female F344/N Rats while Maintaining Normal Hepatic Sphinganine/Sphingosine Ratios

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dc.contributor.author Hendrich, Suzanne
dc.contributor.author Liu, Hongjun
dc.contributor.author Lu, Yun
dc.contributor.author Haynes, Joseph
dc.contributor.author Haynes, Joseph
dc.contributor.author Cunnick, Joan
dc.contributor.author Murphy, Patricia
dc.contributor.author Hendrich, Suzanne
dc.contributor.department Food Science and Human Nutrition
dc.date 2018-02-15T10:51:38.000
dc.date.accessioned 2020-06-30T03:59:55Z
dc.date.available 2020-06-30T03:59:55Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2001
dc.date.embargo 2014-01-29
dc.date.issued 2001-07-07
dc.description.abstract <p>The reaction of th e primar y am ine of fumonisin B1 (FB1) with glucose was hypoth esized to detoxify th is mycotoxin. Eight y 10-day-old fema le F344/N rat s were injected intra peritoneally with dieth ylnitrosam ine (DEN; 15 mg/kg of body weig ht). At 4 wee ks of age, th e wean ed rat s were ran domly assigned to one of four tr eatm ent groups with 20 rat s each. At 9 wee ks of age, four rat s from each tr eatm ent group were kille d. At 12 wee ks, anoth er five rat s from each group were kille d. At 20 wee ks of age, th e rema ining rat s were kille d. In compar ison with th e rat s fed basal diet or FB1-glucose (conta ining 25 pp m of FB1), rat s fed 8 pp m (resid ua l amount of free FB1 in th e FB1- glucose mixtur e) or 25 pp m of FB1 ha d great er alan ine am inotran sfera se activity at 9 an d 20 wee ks of age (P < 0.001), great er endogenous hep at ic prosta glan din E2 production at 20 wee ks of age (P < 0.05), an d significant ly lower plasma cholesterol at 20 wee ks of age (P < 0.01). Placenta l glutath ione S-tran sfera se (PGST )-positive an d γ-glutam yltran sfera se (GGT)-positive altered hepatic foci (AHF) occurr ed only in rat s fed 25 pp m of FB1 at 20 wee ks of age. Hep at ic natura l kille r (NK) cell activities were similar among th e four groups, but th e percenta ge of tota l live r-associat ed mononuclear cells exhibi ting th e NKR-P1bright mark er was significant ly great er in rat s fed FB1- glucose, FB1 (8 pp m) an d FB1 (25 pp m) than in contr ol rat s at 9 wee ks of age, an d FB1-glucose- tr eat ed rat s ha d significant ly lower NKR-P1bright cells as a percenta ge of tota l live r-associat ed mononuclear cells than rat s fed 25 pp m of FB1 at 20 wee ks of age (P < 0.05). PGST- or GGT- positive AHF were not detected in an y tr eatm ent group at 9 or 12 wee ks of age. At 20 wee ks of age, ha lf of th e rat s fed 25 pp m of FB1 ha d PGST- an d GGT-positive AHF . The sp hingan ine (Sa) concentrat ion an d th e Sa/sp hingosine (So) rat io were significant ly great er in th e rat s fed 25 pp m of FB1 diet as compar ed with th e contr ol groups at , respe ctively, 12 or 20 wee ks of age. Therefore, FB -induced hep atotoxicity an d promotion of hep atocarcinogenesis . The Sa/So rat io was not th e most sensitive biomark er of FB1 toxicity.</p>
dc.description.comments <p>Reprinted with permission from <em>Journal of Agricultural and Food Chemistry</em>. 49(8): 4113-4121. doi: <a href="http://www.dx.doi.org/10.1021/jf001529i" target="_blank">10.1021/jf001529i</a>. Copyright 2001 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/fshn_ag_pubs/92/
dc.identifier.articleid 1094
dc.identifier.contextkey 6360043
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath fshn_ag_pubs/92
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/37607
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/fshn_ag_pubs/92/0-ACS_License_ReactionFructoseDetoxifies.docx|||Sat Jan 15 02:29:36 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/fshn_ag_pubs/92/1-ACS_License_ReactionFumonisin.docx|||Sat Jan 15 02:29:36 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/fshn_ag_pubs/92/2001_HendrichS_ReactionFumonisinGlucose.pdf|||Sat Jan 15 02:29:38 UTC 2022
dc.source.uri 10.1021/jf001529i
dc.subject.disciplines Food Science
dc.subject.disciplines Human and Clinical Nutrition
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Department of Microbiology
dc.subject.keywords Department of Veterinary Pathology
dc.subject.keywords Glucose
dc.subject.keywords hepatic
dc.subject.keywords rats
dc.subject.keywords fumonisin
dc.subject.keywords carcinogenesis
dc.title Reaction of Fumonisin with Glucose Prevents Promotion of Hepatocarcinogenesis in Female F344/N Rats while Maintaining Normal Hepatic Sphinganine/Sphingosine Ratios
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isAuthorOfPublication 8c426a1b-1e25-4efc-9283-518a1a6522ed
relation.isOrgUnitOfPublication 4b6428c6-1fda-4a40-b375-456d49d2fb80
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