Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

dc.contributor.author Moon, Sun Hee
dc.contributor.author Lee, Jae Hoon
dc.contributor.author Ahn, Dong
dc.contributor.author Kim, Kee-Tae
dc.contributor.author Park, Yong-Suhn
dc.contributor.author Nah, Seung-Yeol
dc.contributor.author Ahn, Dong
dc.contributor.author Paik, Hyun-Dong
dc.contributor.department Animal Science
dc.date 2018-02-16T04:47:51.000
dc.date.accessioned 2020-06-29T23:41:43Z
dc.date.available 2020-06-29T23:41:43Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.issued 2013-10-28
dc.description.abstract <p>Abstract: The antimicrobial effect of a novel flavonoid (7-<em>O</em>-butylnaringenin) on <em>Helicobacter pylori</em> 26695, 51, and SS1 strains and its inhibitory effect on the urease activity of the strains were evaluated and compared with those of several natural flavonoids. First, various flavonoids were screened for antimicrobial activities using the paper disc diffusion method. Hesperetin and naringenin showed the strongest antimicrobial effects among the natural flavonoids tested, and thus hesperetin and naringenin were selected for comparison with 7-<em>O</em>-butylnaringenin. The antimicrobial effect of 7-<em>O</em>-butylnaringenin was greater than that of the hesperetin and naringenin. <em>H. pylori</em> 51 was more sensitive to 7-<em>O</em>-butylnaringenin (2 log reduction of colony forming units, <em>p </em>< 0.05) than the other two strains at 200 μM. 7-<em>O</em>-Butylnaringenin also showed the highest inhibitory effect against urease activity of <em>H. pylori</em>. Morphological changes of <em>H. pylori</em> 26695 treated with these flavonoids indicated that both hesperetin and 7-<em>O</em>-butylnaringenin at 200 μM damaged the cell membranes.</p>
dc.description.comments <p>This article is from <em>International Journal of Environmental Research and Public Health</em> 10 (2013): 5459–5469, doi:<a href="http://dx.doi.org/10.3390/ijerph10115459" target="_blank">10.3390/ijerph10115459</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/64/
dc.identifier.articleid 1063
dc.identifier.contextkey 6979884
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/64
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9990
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/64/2013_Moon_AntimicrobialEffect.pdf|||Sat Jan 15 01:21:48 UTC 2022
dc.source.uri 10.3390/ijerph10115459
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Bioinformatics
dc.subject.disciplines Meat Science
dc.subject.keywords flavonoid
dc.subject.keywords Helicobacter pylori
dc.subject.keywords 7-O-butylnaringenin
dc.subject.keywords hesperitin
dc.subject.keywords antimicrobial effect
dc.subject.keywords urease activity
dc.title Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication d3386101-2f0d-4375-ab44-ac1addb6a9ad
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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