Preferential Solvation within Hydrophilic Nanocavities and Its Effect on the Folding of Cholate Foldamers Zhao, Yan Zhong, Zhenqi Zhao, Yan Ryu, Eui-Hyun
dc.contributor.department Chemistry 2018-02-17T06:54:19.000 2020-06-30T01:18:23Z 2020-06-30T01:18:23Z Mon Jan 01 00:00:00 UTC 2007 2007-01-01
dc.description.abstract <p>The conformations of three cholate foldamers and one molecular basket were studied by fluorescence and NMR spectroscopy. In nonpolar solvents (e.g., hexane/ethyl acetate or ethyl acetate) mixed with a small amount of a polar solvent (e.g., alcohol or DMSO), the cholate oligomer folded into a helix with the hydrophilic faces of the cholates turned inward. Folding created a hydrophilic nanocavity preferentially solvated by the entrapped polar solvent concentrated from the bulk. This microphase separation of the polar solvent was critical to the folding process. Folding was favored by larger-sized polar solvent molecules, as fewer such molecules could occupy and solvate the nanocavity, thus requiring a smaller extent of phase separation during folding. Folding was also favored by smaller/acyclic nonpolar solvent molecules, probably because they could avoid contact with the OH/NH groups within the nanocavity better than larger/cyclic nonpolar solvent molecules.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Journal of the American Chemical Society </em>129 (2007): 218, doi:<a href="" target="_blank">10.1021/ja0671159</a>. Copyright 2007 American Chemical Society.</p>
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dc.identifier.articleid 1196
dc.identifier.contextkey 7889120
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dc.language.iso en
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dc.source.uri 10.1021/ja0671159
dc.subject.disciplines Chemistry
dc.title Preferential Solvation within Hydrophilic Nanocavities and Its Effect on the Folding of Cholate Foldamers
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dc.type.genre article
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