Preferential Solvation within Hydrophilic Nanocavities and Its Effect on the Folding of Cholate Foldamers

dc.contributor.author Zhao, Yan
dc.contributor.author Zhong, Zhenqi
dc.contributor.author Zhao, Yan
dc.contributor.author Ryu, Eui-Hyun
dc.contributor.department Chemistry
dc.date 2018-02-17T06:54:19.000
dc.date.accessioned 2020-06-30T01:18:23Z
dc.date.available 2020-06-30T01:18:23Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2007
dc.date.issued 2007-01-01
dc.description.abstract <p>The conformations of three cholate foldamers and one molecular basket were studied by fluorescence and NMR spectroscopy. In nonpolar solvents (e.g., hexane/ethyl acetate or ethyl acetate) mixed with a small amount of a polar solvent (e.g., alcohol or DMSO), the cholate oligomer folded into a helix with the hydrophilic faces of the cholates turned inward. Folding created a hydrophilic nanocavity preferentially solvated by the entrapped polar solvent concentrated from the bulk. This microphase separation of the polar solvent was critical to the folding process. Folding was favored by larger-sized polar solvent molecules, as fewer such molecules could occupy and solvate the nanocavity, thus requiring a smaller extent of phase separation during folding. Folding was also favored by smaller/acyclic nonpolar solvent molecules, probably because they could avoid contact with the OH/NH groups within the nanocavity better than larger/cyclic nonpolar solvent molecules.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Journal of the American Chemical Society </em>129 (2007): 218, doi:<a href="http://dx.doi.org/10.1021/ja0671159" target="_blank">10.1021/ja0671159</a>. Copyright 2007 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/203/
dc.identifier.articleid 1196
dc.identifier.contextkey 7889120
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/203
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/14644
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/203/0-L_2007_Zhao_PreferentialSolvation.pdf|||Fri Jan 14 22:22:55 UTC 2022
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dc.source.uri 10.1021/ja0671159
dc.subject.disciplines Chemistry
dc.title Preferential Solvation within Hydrophilic Nanocavities and Its Effect on the Folding of Cholate Foldamers
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 82f430d1-77c0-43c2-8bd5-52f3787cc4ba
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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