Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report Sebbag, Lionel Wehrman, Rita Sebbag, Lionel Reilly, Chris Allbaugh, Rachel Allbaugh, Rachel Ben-Shlomo, Gil Berger, Erika Musser, Margaret
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Clinical Sciences 2020-04-10T21:12:31.000 2020-07-07T05:12:26Z 2020-07-07T05:12:26Z Tue Jan 01 00:00:00 UTC 2019 2019-02-23
dc.description.abstract <p>This report documents the progression of chronic lymphocytic leukemia into diffuse aggressive lymphoma, or Richter’s syndrome, first manifesting as unilateral ophthalmic disease in a 10-year-old coonhound. Following a 1.5-year course of chronic leukemia that was in a clinical remission, the dog was presented for a protruded left globe. Orbital ultrasound revealed a vascular mass located ventromedially and causing indentation of the sclera. Skull computed tomography showed exophthalmos due to a soft tissue mass and concurrent left mandibular bony lysis. Abdominal ultrasound and computed tomography revealed a large right adrenal mass, peritoneal lymphadenopathy, multiple liver nodules, kidney infarcts, and dorsal body wall nodules. A diagnosis of uveal lymphoma with scleral extension was obtained on histopathology after surgical removal of the affected eye. Cancerous cells were large with high-grade proliferative features, consistent with T-cell lymphoma based on immunophenotyping (CD3+/CD20-). The dog was euthanized 2 days postoperatively due to declining systemic condition. Richter’s syndrome is a rare condition, but generally carries a grave prognosis. To the authors’ knowledge, this is the first report of Richter’s syndrome in a veterinary patient presenting with an ophthalmic manifestation.</p>
dc.description.comments <p>This article is published as Wehrman, Rita F, Lionel Sebbag, Chris M Reilly, Rachel A Allbaugh, Gil Ben-Shlomo, Erika P Berger, and Margaret L Musser. "Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report." <em>Journal of Veterinary Medicine and Surgery </em>3, no. 1 (2019): 22. Posted with permission.</p>
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dc.identifier.articleid 1040
dc.identifier.contextkey 17333971
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dc.identifier.submissionpath vcs_pubs/42
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 00:12:51 UTC 2022
dc.subject.disciplines Ophthalmology
dc.subject.disciplines Small or Companion Animal Medicine
dc.title Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report
dc.type article
dc.type.genre article
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