Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines

dc.contributor.author Acar, Handan
dc.contributor.author Banerjee, Saikat
dc.contributor.author Shi, Heliang
dc.contributor.author Jamshidi, Reihaneh
dc.contributor.author Hashemi, Nicole
dc.contributor.author Hashemi, Nicole
dc.contributor.author Cho, Michael
dc.contributor.author Montazami, Reza
dc.contributor.department Ames Laboratory
dc.contributor.department Biomedical Sciences
dc.contributor.department Mechanical Engineering
dc.date 2018-02-17T18:18:46.000
dc.date.accessioned 2020-06-30T06:03:49Z
dc.date.available 2020-06-30T06:03:49Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2016
dc.date.issued 2016-04-01
dc.description.abstract <p>Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.</p>
dc.description.comments <p>This is an article from <em>Materials</em> 9 (2016): 321, doi: <a href="http://dx.doi.org/10.3390/ma9050321" target="_blank">10.3390/ma9050321</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/me_pubs/197/
dc.identifier.articleid 1198
dc.identifier.contextkey 8803861
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/197
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/55051
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/me_pubs/197/2016_HashemiN_TransientBiocompatiblePolymeric.pdf|||Fri Jan 14 21:59:06 UTC 2022
dc.source.uri 10.3390/ma9050321
dc.subject.disciplines Mechanical Engineering
dc.subject.disciplines Polymer Chemistry
dc.subject.keywords transient platform
dc.subject.keywords controlled release
dc.subject.keywords polymer platform
dc.subject.keywords long-term release
dc.title Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines
dc.type article
dc.type.genre article
dspace.entity.type Publication
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