Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines Acar, Handan Banerjee, Saikat Shi, Heliang Jamshidi, Reihaneh Hashemi, Nicole Hashemi, Nicole Cho, Michael Montazami, Reza
dc.contributor.department Ames Laboratory
dc.contributor.department Biomedical Sciences
dc.contributor.department Mechanical Engineering 2018-02-17T18:18:46.000 2020-06-30T06:03:49Z 2020-06-30T06:03:49Z Fri Jan 01 00:00:00 UTC 2016 2016-04-01
dc.description.abstract <p>Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.</p>
dc.description.comments <p>This is an article from <em>Materials</em> 9 (2016): 321, doi: <a href="" target="_blank">10.3390/ma9050321</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1198
dc.identifier.contextkey 8803861
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/197
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 21:59:06 UTC 2022
dc.source.uri 10.3390/ma9050321
dc.subject.disciplines Mechanical Engineering
dc.subject.disciplines Polymer Chemistry
dc.subject.keywords transient platform
dc.subject.keywords controlled release
dc.subject.keywords polymer platform
dc.subject.keywords long-term release
dc.title Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines
dc.type article
dc.type.genre article
dspace.entity.type Publication
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