Fiber Based Approaches as Medicine Delivery Systems

Date
2016-01-01
Authors
Sharifi, Farrokh
Sooriyarachchi, Avinash
Hashemi, Nicole
Altural, Hayriye
Montazami, Reza
Rylander, Marissa
Hashemi, Nicole
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Altmetrics
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Research Projects
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Mechanical Engineering
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Abstract

The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro- and nanofibers for this purpose. The reasons for this growing interest include these materials’ high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.

Description
<p>This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in <em>ACS Biomaterials Science and Engineering</em>, copyright © American Chemical Society after peer review. To access the final edited and published work see DOI: <a href="https://dx.doi.org/10.1021/acsbiomaterials.6b00281" target="_blank">10.1021/acsbiomaterials.6b00281</a>. Posted with permission.</p>
Keywords
drug delivery, electrospinning, micro- and nanofiber fabrication, microfluidics, rotary spinning, self-assembly, wet spinning
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