Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones
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At ambient temperature, triacetic acid lactone reacts with amines to produce 4-amino-2-pyrones. If the temperature is raised to 100 °C, 4-hydroxy-2-pyridones are generated.
This is a manuscript of an article published as Kraus, George A., Umayangani K. Wanninayake, and Jashaun Bottoms. "Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones." Tetrahedron Letters 57, no. 11 (2016): 1293-1295. 10.1016/j.tetlet.2016.02.043. Posted with permission.