Synthesis of isophthalates from methyl coumalate
Methyl coumalate reacts with enol ethers to form stable adducts which can be converted into isophthalates in good to excellent yields. Alkyl vinyl ethers afford higher yields of isophthalates than enol silyl ethers. The adduct of the enol silyl ether of acetophenone with methyl coumalate reacted with PTSA to produce a styryl coumalate.
This article is published as Kraus, George A. and Shuai Wang. "Synthesis of isophthalates from methyl coumalate." RSC Advances 7, no. 89 (2017): 56760-56763. DOI: 10.1039/C7RA12935A. Posted with permission.