A Comparison of the Genetic Factors Influencing Host Response to Infection with One of Two Isolates of Porcine Reproductive and Respiratory Syndrome Virus

dc.contributor.author Hess, Andrew
dc.contributor.author Boddicker, Nicholas
dc.contributor.author Rowland, Bob
dc.contributor.author Lunney, Joan
dc.contributor.author Plastow, Graham
dc.contributor.author Dekkers, Jack
dc.date 2018-08-25T22:31:25.000
dc.date.accessioned 2020-06-29T23:36:11Z
dc.date.available 2020-06-29T23:36:11Z
dc.date.issued 2015-01-01
dc.description.abstract <p>Host genetic differences in viral load (VL) and weight gain (WG) during porcine reproductive and respiratory syndrome virus (PRRSV) challenge were assessed for thirteen trials of ~200 commercial crossbred piglets each, from several different commercial suppliers. Piglets were experimentally infected with PRRSV isolates NVSL-97-7895 (NVSL) or KS-2006-72109 (KS06). VL and WG were moderately heritable and were antagonistically related for both virus isolates. The genetic correlation of host response to NVSL with host response to KS06 was high for both VL and WG. Consistent with previous findings, animals that were heterozygous (AB) for the WUR10000125 (WUR) marker on Chromosome 4 (SSC4) had significantly lower VL than their AA counterparts when infected with either virus isolate; however, a significant increase in WG was only observed when piglets were infected with the NVSL isolate. These results suggest that selecting for increased resistance or reduced susceptibility to PRRSV may be effective across virus isolates. Selecting for the AB genotype for WUR is expected to reduce VL across PRRSV isolates but its effect on WG during infection may differ between virus isolates.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol661/iss1/93/
dc.identifier.articleid 2139
dc.identifier.contextkey 6761551
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-1344
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol661/iss1/93
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9211
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol661/iss1/93/R3030.pdf|||Sat Jan 15 02:31:03 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Bioinformatics
dc.subject.disciplines Computational Biology
dc.subject.disciplines Genetics
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.keywords ASL R3030
dc.subject.keywords Animal Science
dc.title A Comparison of the Genetic Factors Influencing Host Response to Infection with One of Two Isolates of Porcine Reproductive and Respiratory Syndrome Virus
dc.type article
dc.type.genre swine
dspace.entity.type Publication
relation.isJournalIssueOfPublication 6758d906-7d2a-4198-98dc-f5f25ab96561
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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