Quantitative Effect of Porcine Reproductive Respiratory Syndrome Virus on Pig Growth and Immune Response

dc.contributor.author Greiner, L.
dc.contributor.author Stahly, Tim
dc.contributor.author Stabel, T.
dc.date 2018-02-13T00:17:03.000
dc.date.accessioned 2020-07-02T07:00:34Z
dc.date.available 2020-07-02T07:00:34Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 1999
dc.date.embargo 2012-08-18
dc.date.issued 1999
dc.description.abstract <p>Forty-eight pigs from a herd naïve for porcine reproductive respiratory syndrome virus (PRRS) were weaned, placed in isolation chambers, and oral-nasally inoculated with 2 ml of 10 4 JA142 PRRS virus. For each pig, body weight, feed intake, and serum concentration of PRRS virus titers, gamma-interferon (γ-IFN), and alpha-1- glycoprotein (AGP) were determined every 4 days for 24 days post-inoculation to determine the effect of PRRS exposure on growth and immune response in pigs and to quantify the relationship between serum virus concentration and pig growth. Serum virus titers and γ-IFN, both peaked at 4 days post-inoculation, and then declined steadily throughout the 24 day study. As expected, serum AGP responses were delayed with peak concentrations occurring 12 days post-inoculation. Body weight gains and feed intakes of individual pigs were quantitatively related to the animal’s serum concentration of virus titers and to a lessor degree to serum concentration of γ-IFN and AGP. Specifically, each additional 10-fold of serum virus titer was associated with a mean reduction of .018 kg in daily pig gain and .028 kg in daily pig feed consumption. These data indicate that the magnitude of biological responses that occur in pigs infected with PRRS is directly related to the animal’s serum virus concentration.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/swinereports_1998/5/
dc.identifier.articleid 1014
dc.identifier.contextkey 3232440
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_1998/5
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91145
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/swinereports_1998/5/asl_1566.pdf|||Sat Jan 15 00:31:19 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1566
dc.title Quantitative Effect of Porcine Reproductive Respiratory Syndrome Virus on Pig Growth and Immune Response
dc.type article
dc.type.genre nutrition
dspace.entity.type Publication
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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