Y Fuse? Sex Chromosome Fusions in Fishes and Reptiles

dc.contributor.author Pennell, Matthew
dc.contributor.author Kirkpatrick, Mark
dc.contributor.author Valenzuela, Nicole
dc.contributor.author Otto, Sarah
dc.contributor.author Vamosi, Jana
dc.contributor.author Peichel, Catherine
dc.contributor.author Valenzuela, Nicole
dc.contributor.author Kitano, Jun
dc.contributor.department Ecology, Evolution and Organismal Biology
dc.date 2018-02-17T11:01:01.000
dc.date.accessioned 2020-06-30T02:16:30Z
dc.date.available 2020-06-30T02:16:30Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2015-01-01
dc.description.abstract <p>Chromosomal fusion plays a recurring role in the evolution of adaptations and reproductive isolation among species, yet little is known of the evolutionary drivers of chromosomal fusions. Because sex chromosomes (X and Y in male heterogametic systems, Z and W in female heterogametic systems) differ in their selective, mutational, and demographic environments, those differences provide a unique opportunity to dissect the evolutionary forces that drive chromosomal fusions. We estimate the rate at which fusions between sex chromosomes and autosomes become established across the phylogenies of both fishes and squamate reptiles. Both the incidence among extant species and the establishment rate of Y-autosome fusions is much higher than for X-autosome, Z-autosome, or W-autosome fusions. Using population genetic models, we show that this pattern cannot be reconciled with many standard explanations for the spread of fusions. In particular, direct selection acting on fusions or sexually antagonistic selection cannot, on their own, account for the predominance of Y-autosome fusions. The most plausible explanation for the observed data seems to be (a) that fusions are slightly deleterious, and (b) that the mutation rate is male-biased or the reproductive sex ratio is female-biased. We identify other combinations of evolutionary forces that might in principle account for the data although they appear less likely. Our results shed light on the processes that drive structural changes throughout the genome.</p>
dc.description.comments <p>This is an article from <em>PLOS Genetics</em> 11 (2015): 1, doi:<a href="http://dx.doi.org/10.1371/journal.pgen.1005237" target="_blank">10.1371/journal.pgen.1005237</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/eeob_ag_pubs/125/
dc.identifier.articleid 1126
dc.identifier.contextkey 8037288
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath eeob_ag_pubs/125
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/22987
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/eeob_ag_pubs/125/2015_Valenzuela_YFuseSex.pdf|||Fri Jan 14 19:23:01 UTC 2022
dc.source.uri 10.1371/journal.pgen.1005237
dc.subject.disciplines Ecology and Evolutionary Biology
dc.subject.disciplines Evolution
dc.subject.disciplines Genetics
dc.subject.disciplines Terrestrial and Aquatic Ecology
dc.title Y Fuse? Sex Chromosome Fusions in Fishes and Reptiles
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication cc984ec0-a821-45f2-895d-e5fd76250b94
relation.isOrgUnitOfPublication 6fa4d3a0-d4c9-4940-945f-9e5923aed691
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