Synthesis of heteroaromatic natural products

Date
2009-01-01
Authors
Guo, Haitao
Journal Title
Journal ISSN
Volume Title
Publisher
Source URI
Altmetrics
Authors
Research Projects
Organizational Units
Chemistry
Organizational Unit
Journal Issue
Series
Abstract

The synthesis of biologically active natural products has been used for the discovery of new drugs. Organic synthesis is designed for a target molecule like a novel compound by selecting optimal reactions from optimal starting materials. Each reaction and each step of a synthesis should give a good yield for the product with little work.

In this thesis, we explored both total synthesis and methodology of several natural products and analogs, especially heteroaromatic natural compounds. Chapter 1 describes an efficient synthesis of 2-substituted and 2,3-disubstituted indoles via a two-step approach in one pot involving a six-electron ring closure. Chapter 2 describes the direct synthesis of neocryptolepine in four steps in two pots. Chapter 3 is about synthesis studies towards the unique κ opioid receptor agonist salvinorin A. Chapter 4 describes a direct approach to the synthesis of methyllycaconitine, one of the diterpenoid alkaloids.

Description
Keywords
heteroaromatic, indole, methyllycaconitine, neocryptolepine, salvinorin A
Citation