Field and Experimental Assessment of PRRSV Evolution Yoon, Kyoung-Jin Chang, Chih-Cheng Zimmerman, Jeffrey Harmon, Karen 2018-02-13T00:01:07.000 2020-07-02T07:01:14Z 2020-07-02T07:01:14Z Mon Jan 01 00:00:00 UTC 2001 2012-08-13 2001-01-01
dc.description.abstract <p>The genetic and antigenic stability of porcine reproductive and respiratory syndrome (PRRS) virus during infection in pigs was assessed using field and experimental data. Among field isolates, we found that PRRS virus varied both genetically and antigenically. Even within the same farm, various phenotypic strains of PRRS virus were present simultaneously. Experimentally, we demonstrated that PRRS virus “quasi-species” appeared over time as the virus replicated in animals. Although the degree of genotypic changes in the gene coding for the major envelope protein (i.e., open reading frame 5) was less than expected based on field observations; some mutants appear to have been changed significantly. Overall, our observations suggest that persistence of PRRS virus in pigs may be attributed to viral mutation, although the actual role of viral mutation in persistent PRRS virus infection remains to be determined. The presence of various phenotypic strains within the same farm or herd may account for the apparent ineffectiveness of PRRS control by monovalent vaccine.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1042
dc.identifier.contextkey 3210485
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_2000/46
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/|||Sat Jan 15 00:21:55 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R686
dc.title Field and Experimental Assessment of PRRSV Evolution
dc.type article
dc.type.genre health
dspace.entity.type Publication
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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