Aptamers for Diagnostics with Applications for Infectious Diseases

Date
2019-04-10
Authors
Ilgu, Muslum
Fazlioglu, Rezzan
Nilsen-Hamilton, Marit
Ozturk, Meric
Ozsurekci, Yasemin
Nilsen-Hamilton, Marit
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Biochemistry, Biophysics and Molecular Biology
Abstract

Aptamers are in vitro selected oligonucleotides (DNA, RNA, oligos with modified nucleotides) that can have high affinity and specificity for a broad range of potential targets with high affinity and specificity. Here we focus on their applications as biosensors in the diagnostic field, although they can also be used as therapeutic agents. A small number of peptide aptamers have also been identified. In analytical settings, aptamers have the potential to extend the limit of current techniques as they offer many advantages over antibodies and can be used for real-time biomarker detection, cancer clinical testing, and detection of infectious microorganisms and viruses. Once optimized and validated, aptasensor technologies are expected to be highly beneficial to clinicians by providing a larger range and more rapid output of diagnostic readings than current technologies and support personalized medicine and faster implementation of optimal treatments.

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This chapter is published as Ilgu, Muslum, Rezzan Fazlioglu, Meric Ozturk, Yasemin Ozsurekci, and Marit Nilsen-Hamilton. "Aptamers for Diagnostics with Applications for Infectious Diseases." In Recent Advances in Analytical Chemistry. IntechOpen, 2019. doi: 10.5772/intechopen.84867.

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