Persistent infection with bovine herpesvirus-1: a rabbit model

dc.contributor.author Rock, Daniel
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-08-16T19:25:18.000
dc.date.accessioned 2020-07-02T05:57:44Z
dc.date.available 2020-07-02T05:57:44Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 1981
dc.date.issued 1981
dc.description.abstract <p>This study consisted of two parts: (1) an examination of the rabbit as a laboratory model for the study of persistent bovine herpesvirus-1 infection (BHV-1) and (2) an examination of the pathogenesis of acute and recurrent BHV-1 infection in rabbits following conjunctival inoculation;Persistent infection with BHV-1 was established in all rabbits following conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance of recurrent ocular lesions were observed in persistently infected rabbits. BHV-1 was reactivated predictably and shed from all persistently infected rabbits following the administration of dexamethasone. Recurrent virus shed and ocular lesions were restricted to the inoculated eye;The pathogenesis of acute and recurrent BHV-1 infection in rabbits following conjunctival inoculation was studied using virus isolation, fluorescent antibody staining, and histopathologic examination. BHV-1 produced a moderate to severe conjunctivitis following conjunctival inoculation. Infection was confined to ocular tissues and the trigeminal ganglion of the inoculated side. Generalization of infection to the central nervous system was not observed;Recurrent BHV-1 infection, induced following dexamethasone treatment, was confined to ocular tissues and the trigeminal ganglia. BHV-1 was isolated from the trigeminal ganglia of persistently infected rabbits. In addition, virus specific fluorescent cells were detected in the trigeminal ganglia of dexamethasone treated rabbits prior to the appearance of virus in ocular tissues. These observations suggest that BHV-1 persists in the trigeminal ganglia of rabbits following conjunctival inoculation.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/6993/
dc.identifier.articleid 7992
dc.identifier.contextkey 6304137
dc.identifier.doi https://doi.org/10.31274/rtd-180813-5379
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/6993
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/79820
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/6993/r_8209168.pdf|||Sat Jan 15 01:31:37 UTC 2022
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Veterinary Medicine
dc.subject.keywords Veterinary microbiology and preventive medicine
dc.subject.keywords Veterinary microbiology
dc.title Persistent infection with bovine herpesvirus-1: a rabbit model
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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