Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

Date
2015-10-01
Authors
Qin, Shangshang
Qi, Hui
Zhang, Qijing
Zhao, Di
Liu, Zhen-Zhen
Tian, Hao
Xu, Lijuan
Xu, Hui
Zhou, Mengmeng
Feng, Xianju
Liu, Hong-Min
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Abstract

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.

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This article is published as Qin, Shangshang, Hui Qi, Qijing Zhang, Di Zhao, Zhen-Zhen Liu, Hao Tian, Lijuan Xu et al. "Emergence of extensively drug-resistant Proteus mirabilis harboring a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant, SGI1-Z." Antimicrobial agents and chemotherapy 59, no. 10 (2015): 6601-6604. doi: 10.1128/AAC.00292-15. Posted with permission.

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