Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy
Date
2022
Authors
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley Periodicals LLC
Authors
Research Projects
Organizational Units
Organizational Unit
Organizational Unit
Organizational Unit
Journal Issue
Is Version Of
relationships.hasVersion
Series
Department
Veterinary Clinical SciencesBiomedical SciencesVeterinary Diagnostic and Production Animal Medicine
Abstract
Background
Activity of the circulating renin-angiotensin-aldosterone system (RAAS) has not been comprehensively characterized in cats with systemic hypertension (SH) or cardiomyopathy (CM), and the effects of furosemide or amlodipine treatment on the RAAS have not been fully evaluated in cats.
Hypothesis/Objectives
To document RAAS activity in cats with SH or CM compared to healthy cats and determine how RAAS profiles change with furosemide or amlodipine treatment.
Animals
Sixty-six client-owned cats: 15 with SH (7 amlodipine-treated, 8 untreated), 17 with advanced CM (7 furosemide-treated, 10 not furosemide-treated), and 34 healthy cats.
Methods
Equilibrium concentrations of RAAS peptides and aldosterone were quantified in serum samples by liquid chromatography-mass spectrometry. Variables were compared between groups using Kruskal-Wallis analysis with post hoc Holms-corrected Dunn's testing.
Results
Compared with healthy cats, cats with CM had higher concentrations of angiotensin I, aldosterone, and plasma renin activity (all P < .01), and these differences remained significant (P < .03) after considering subgroups of untreated or furosemide-treated cats. Compared with healthy cats, untreated cats with SH showed no differences in RAAS biomarkers, whereas amlodipine-treated cats had higher concentrations of angiotensins I, II, III, IV, and 1-7, aldosterone, and plasma renin activity (all P < .03). Multivariable analysis determined that furosemide and amlodipine treatments were independent predictors of increased RAAS biomarker concentrations.
Conclusions and Clinical Importance
Cats with CM had increased RAAS activity, whereas cats with untreated SH did not. Furosemide and amlodipine both led to nonspecific activation of both classical and alternative RAAS pathways in cats.
Comments
This is the published version of the following article: Ward, Jessica L., Emilie Guillot, Oliver Domenig, Wendy A. Ware, Lingnan Yuan, and Jonathan P. Mochel. "Circulating renin‐angiotensin‐aldosterone system activity in cats with systemic hypertension or cardiomyopathy." Journal of Veterinary Internal Medicine (2022). DOI: 10.1111/jvim.16401. Copyright 2022 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).
Posted with permission.