Video Review of Baseline Performance on Global Ratings in a Double‐Blind Placebo Surgery Trial

dc.contributor.author McRae, Cynthia
dc.contributor.author Russell, Daniel
dc.contributor.author Caspari, Jennifer
dc.contributor.author Rusell, Daniel
dc.contributor.author Ellgring, Heiner
dc.contributor.author Bezzant, Chris
dc.contributor.author Greene, Paul
dc.contributor.author Fahn, Stanley
dc.contributor.department Human Development and Family Studies
dc.date 2018-08-26T15:29:02.000
dc.date.accessioned 2020-06-30T04:06:52Z
dc.date.available 2020-06-30T04:06:52Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.embargo 2019-08-12
dc.date.issued 2018-08-12
dc.description.abstract <p>BACKGROUND A randomized double‐blind sham surgery‐controlled trial was conducted to determine the effectiveness of implantation of human embryonic dopamine neurons into the putamen of patients with advanced Parkinson's disease (PD). The present analyses determined whether patients viewing a video of themselves performing motor activities off medications at baseline would affect self‐ratings 12 months later on the Global Rating Scale (GRS).</p> <p>OBJECTIVES To examine changes in GRS scores pre‐/post‐video review for the total sample; to examine differences in scores between actual implant and sham groups, as well as perceived groups pre‐ and post‐video review; to examine differences among four subgroups of patients based on actual and perceived treatment (i.e., actual implant/perceived implant).</p> <p>METHODS Forty participants were recruited and randomly assigned to receive either neural implantation or sham surgery. The primary outcome variable was a one‐item GRS ranging from ‐3 (much worse since surgery) to +3 (much improved since surgery). At 12 months (before the blind was lifted) patients rated themselves on the GRS before and after viewing the baseline video.</p> <p>RESULTS Total sample GRS scores improved after the video (P = .001). There were no differences between the actual implant and sham groups before or after the video, but there were differences between perceived groups at both times (P < .001). Among subgroups, improvement after the video was found only in the group receiving the implant but who thought sham (P = .011).</p> <p>CONCLUSION When self‐ratings are an outcome variable, review of baseline videos is recommended before making comparative ratings.</p>
dc.description.comments <p>This accepted article is published as McRae, C., Caspari, J., Russell, D.W., Ellgring,H., Bezzant, C., Greene, P., Fahn, S., Video Review of Baseline Performance on Global Ratings in a Double‐Blind Placebo Surgery Trial. <em>Movement Disorders Clinical Practice</em>. 2018. Doi: <a href="https://dx.doi.org/10.1002/mdc3.12666" target="_blank">10.1002/mdc3.12666</a>. Posted with permission. </p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/hdfs_pubs/99/
dc.identifier.articleid 1100
dc.identifier.contextkey 12669426
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath hdfs_pubs/99
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/38549
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/hdfs_pubs/99/0-2018_license__RussellDW_VideoReviewBaseline.pdf|||Sat Jan 15 02:39:20 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/hdfs_pubs/99/2018_RussellDW_acceptedManu_videoreviewbaselinePerformanceGlobal_Ratings.pdf|||Sat Jan 15 02:39:22 UTC 2022
dc.source.uri 10.1002/mdc3.12666
dc.subject.disciplines Family, Life Course, and Society
dc.subject.disciplines Human and Clinical Nutrition
dc.subject.disciplines Neurology
dc.subject.disciplines Neurosciences
dc.subject.disciplines Public Health
dc.subject.keywords Parkinson's disease
dc.subject.keywords Double-blind
dc.subject.keywords Placebo surgery
dc.subject.keywords Video review
dc.subject.keywords Global ratings
dc.title Video Review of Baseline Performance on Global Ratings in a Double‐Blind Placebo Surgery Trial
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 891a6ae0-1bc5-495c-9208-5334230c50a7
relation.isOrgUnitOfPublication aa55ac20-60f6-41d8-a7d1-c7bf09de0440
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