Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases

Date
2015-04-01
Authors
Gendelman, Howard
Anatharam, Vellareddy
Bronich, Tatiana
Ghaisas, Shivani
Jin, Huajun
Kanthasamy, Anumantha
Liu, Xinming
McMillan, JoEllyn
Mosley, R. Lee
Narasimhan, Balagi
Mallapragada, Surya
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Abstract

Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious and degenerative nervous system disorders. These, in whole or in part, are a significant societal burden due to growth in numbers of affected people and in disease severity. Lost productivity of the patient and his or her caregiver, and the emotional and financial burden cannot be overstated. The need for improved health care, treatment and diagnostics is immediate. A means to such an end is nanotechnology. Indeed, recent developments of health-care enabling nanotechnologies and nanomedicines range from biomarker discovery including neuroimaging to therapeutic applications for degenerative, inflammatory and infectious disorders of the nervous system. This review focuses on the current and future potential of the field to positively affect clinical outcomes.

From the Clinical Editor

Many nervous system disorders remain unresolved clinical problems. In many cases, drug agents simply cannot cross the blood-brain barrier (BBB) into the nervous system. The advent of nanomedicines can enhance the delivery of biologically active molecules for targeted therapy and imaging. This review focused on the use of nanotechnology for degenerative, inflammatory, and infectious diseases in the nervous system.

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This article is published as Gendelman, Howard E., Vellareddy Anantharam, Tatiana Bronich, Shivani Ghaisas, Huajun Jin, Anumantha G. Kanthasamy, Xinming Liu et al. "Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases." Nanomedicine: Nanotechnology, Biology and Medicine 11, no. 3 (2015): 751-767. 10.1016/j.nano.2014.12.014. Posted with permission.

Keywords
Nanoeuromedicine, Diagnostics, Neurodegenerative disorders, Nanotechnology, Drug development
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