Research on Persistent Colonization of Pigs by Salmonella typhimurium and the Effects of Transportation Related Stress on Shedding of Salmonella typhimurium

dc.contributor.author Isaacson, Richard
dc.date 2018-08-13T18:36:33.000
dc.date.accessioned 2020-07-02T06:17:11Z
dc.date.available 2020-07-02T06:17:11Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 1996
dc.date.issued 1996-01-12
dc.description.abstract <p>Research in my laboratory has been on the mechanism(s) employed by Salmonella typhimurium to persistently colonize pigs and on the factors contributing to increased shedding of S. typhimurium by pigs at slaughter. A phenotype of S. typhimurium has been identified that attaches to epithelial cells isolated from the pig small intestine. Cells of the adhesive phenotype produce pili that may be the adhesin, while cells of the non-adhesive phenotype do not. Cells of the adhesive phenotype also produce 10-12 unique envelope proteins and several new surface antigens. Adhesive cells are more readily phagocytized by porcine neutrophils and macrophages and have a much greater degree of intracellular survival in the phagocytic cells. Cells can readily shift between the two phenotypes. In the laboratory the rate of change is between 10-2 and 10-4. When pigs were challenged with cells in the nonadhesive phenotype, only cells in the adhesive phenotype were recovered from pigs. Both phenotypes were of equal virulence. This demonstrates that the adhesive phenotype is important in pigs. A nonadhesive mutant was isolated and shown to be less virulent in mice and was more rapidly cleared from the intestinal tract of pigs. The role of the adhesin and the other properties associated with the adhesive phenotype are being investigated with the intent of learning how pigs can be long term carriers of S. typhimurium.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/safepork/1996/allpapers/12/
dc.identifier.articleid 1011
dc.identifier.contextkey 6009985
dc.identifier.doi https://doi.org/10.31274/safepork-180809-150
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath safepork/1996/allpapers/12
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/83189
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/safepork/1996/allpapers/12/1996_IsaacsonRE_ResearchPersistentColonization.pdf|||Fri Jan 14 19:04:20 UTC 2022
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Bacterial Infections and Mycoses
dc.subject.disciplines Epidemiology
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Research on Persistent Colonization of Pigs by Salmonella typhimurium and the Effects of Transportation Related Stress on Shedding of Salmonella typhimurium
dc.type event
dc.type.genre article
dspace.entity.type Publication
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