Studies directed to the total synthesis of biologically active natural products
dc.contributor.advisor | George A. Kraus | |
dc.contributor.author | Liras, Spiros | |
dc.contributor.department | Department of Chemistry | |
dc.date | 2018-08-23T00:30:20.000 | |
dc.date.accessioned | 2020-06-30T07:11:00Z | |
dc.date.available | 2020-06-30T07:11:00Z | |
dc.date.copyright | Mon Jan 01 00:00:00 UTC 1990 | |
dc.date.issued | 1990 | |
dc.description.abstract | <p>The total synthesis of biologically active, naturally occurring substances is an ambitious task. Fascinating new methods have been developed for the synthesis of natural products. We discuss the following accomplishments: (1) The short and convergent synthesis of 4,1-Bisdeoxydaunamycinone by Claisen/Diels-Alder sequence. (2) The regiochemical studies on the Diels-Alder reaction of electron-rich dienes and activated dienophiles, and the effort toward the aza-tricyclic moiety of atisine-type alkaloids. (3) The formation of bicyclic and monocyclic intermediates via silyl radical induced cyclizations, and the first chemoselective studies on silicon radicals.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/rtd/11202/ | |
dc.identifier.articleid | 12201 | |
dc.identifier.contextkey | 6444460 | |
dc.identifier.doi | https://doi.org/10.31274/rtd-180813-10284 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | rtd/11202 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/64434 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/rtd/11202/r_9035097.pdf|||Fri Jan 14 18:45:08 UTC 2022 | |
dc.subject.disciplines | Organic Chemistry | |
dc.subject.keywords | Chemistry | |
dc.subject.keywords | Organic chemistry | |
dc.title | Studies directed to the total synthesis of biologically active natural products | |
dc.type | dissertation | |
dc.type.genre | dissertation | |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11 | |
thesis.degree.level | dissertation | |
thesis.degree.name | Doctor of Philosophy |
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