Studies directed to the total synthesis of biologically active natural products

dc.contributor.advisor George A. Kraus Liras, Spiros
dc.contributor.department Chemistry 2018-08-23T00:30:20.000 2020-06-30T07:11:00Z 2020-06-30T07:11:00Z Mon Jan 01 00:00:00 UTC 1990 1990
dc.description.abstract <p>The total synthesis of biologically active, naturally occurring substances is an ambitious task. Fascinating new methods have been developed for the synthesis of natural products. We discuss the following accomplishments: (1) The short and convergent synthesis of 4,1-Bisdeoxydaunamycinone by Claisen/Diels-Alder sequence. (2) The regiochemical studies on the Diels-Alder reaction of electron-rich dienes and activated dienophiles, and the effort toward the aza-tricyclic moiety of atisine-type alkaloids. (3) The formation of bicyclic and monocyclic intermediates via silyl radical induced cyclizations, and the first chemoselective studies on silicon radicals.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 12201
dc.identifier.contextkey 6444460
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/11202
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 18:45:08 UTC 2022
dc.subject.disciplines Organic Chemistry
dc.subject.keywords Chemistry
dc.subject.keywords Organic chemistry
dc.title Studies directed to the total synthesis of biologically active natural products
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11 dissertation Doctor of Philosophy
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