CAR T Cell Therapy

dc.contributor.author Bonnett, Megan
dc.contributor.department Biomedical Sciences
dc.contributor.majorProfessor Jon Mochel
dc.date 2019-09-21T14:08:15.000
dc.date.accessioned 2020-06-30T01:32:39Z
dc.date.available 2020-06-30T01:32:39Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2019
dc.date.issued 2019-01-01
dc.description.abstract <p>With chemotherapy and radiation being the most common forms of cancer treatment, some cancer cells are able to develop resistance and persist in the body. Because of this resistance, there is a need for a new cancer therapy that can attack these persistent cells. CAR T cell therapy utilizes the patient’s own immune system to attack and potentially eliminate these cancer cells. These cells have successfully been used against B cell malignancies, however, not much success has been seen when used against solid tumors. Solid tumors pose many challenges and threats these T cells must overcome in order to produce any anti-tumor effect. Challenges researchers run into include finding a suitable antigen to target, successfully trafficking to and infiltrating the tumor, and overcoming the microenvironment of the tumor. Researchers are continuously trying to figure out ways to overcome these challenges and increase the success of CAR T cell therapy</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/creativecomponents/141/
dc.identifier.articleid 1243
dc.identifier.contextkey 14333319
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath creativecomponents/141
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/16670
dc.source.bitstream archive/lib.dr.iastate.edu/creativecomponents/141/CAR_T_cell_therapy_paper_2.docx|||Fri Jan 14 20:14:14 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/creativecomponents/141/auto_convert.pdf|||Fri Jan 14 20:14:15 UTC 2022
dc.subject.disciplines Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subject.keywords CAR T Cell
dc.subject.keywords cancer treatment
dc.subject.keywords chimeric antigen receptor
dc.subject.keywords B cell malignancies
dc.title CAR T Cell Therapy
dc.type article
dc.type.genre creativecomponent
dspace.entity.type Publication
relation.isOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
thesis.degree.discipline Biomedical Sciences
thesis.degree.level creativecomponent
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