CAR T Cell Therapy

dc.contributor.author	Bonnett, Megan
dc.contributor.department	Biomedical Sciences
dc.contributor.majorProfessor	Jon Mochel
dc.date	2019-09-21T14:08:15.000
dc.date.accessioned	2020-06-30T01:32:39Z
dc.date.available	2020-06-30T01:32:39Z
dc.date.copyright	Tue Jan 01 00:00:00 UTC 2019
dc.date.issued	2019-01-01
dc.description.abstract	<p>With chemotherapy and radiation being the most common forms of cancer treatment, some cancer cells are able to develop resistance and persist in the body. Because of this resistance, there is a need for a new cancer therapy that can attack these persistent cells. CAR T cell therapy utilizes the patient’s own immune system to attack and potentially eliminate these cancer cells. These cells have successfully been used against B cell malignancies, however, not much success has been seen when used against solid tumors. Solid tumors pose many challenges and threats these T cells must overcome in order to produce any anti-tumor effect. Challenges researchers run into include finding a suitable antigen to target, successfully trafficking to and infiltrating the tumor, and overcoming the microenvironment of the tumor. Researchers are continuously trying to figure out ways to overcome these challenges and increase the success of CAR T cell therapy</p>
dc.format.mimetype	application/pdf
dc.identifier	archive/lib.dr.iastate.edu/creativecomponents/141/
dc.identifier.articleid	1243
dc.identifier.contextkey	14333319
dc.identifier.s3bucket	isulib-bepress-aws-west
dc.identifier.submissionpath	creativecomponents/141
dc.identifier.uri	https://dr.lib.iastate.edu/handle/20.500.12876/16670
dc.source.bitstream	archive/lib.dr.iastate.edu/creativecomponents/141/CAR_T_cell_therapy_paper_2.docx\|\|\|Fri Jan 14 20:14:14 UTC 2022
dc.source.bitstream	archive/lib.dr.iastate.edu/creativecomponents/141/auto_convert.pdf\|\|\|Fri Jan 14 20:14:15 UTC 2022
dc.subject.disciplines	Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subject.keywords	CAR T Cell
dc.subject.keywords	cancer treatment
dc.subject.keywords	chimeric antigen receptor
dc.subject.keywords	B cell malignancies
dc.title	CAR T Cell Therapy
dc.type	article
dc.type.genre	creativecomponent
dspace.entity.type	Publication
relation.isOrgUnitOfPublication	184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
thesis.degree.discipline	Biomedical Sciences
thesis.degree.level	creativecomponent

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