Inductively coupled plasma: fundamental particle investigations with laser ablation and applications in magnetic sector mass spectrometry

Date
2008-01-01
Authors
Saetveit, Nathan
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Altmetrics
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Research Projects
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Chemistry
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Abstract

Particle size effects and elemental fractionation in laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) are investigated with nanosecond and femtosecond laser ablation, differential mobility analysis, and magnetic sector ICP-MS. Laser pulse width was found to have a significant influence on the LA particle size distribution and the elemental composition of the aerosol and thus fractionation. Emission from individual particles from solution nebulization, glass, and a pressed powder pellet are observed with high speed digital photography. The presence of intact particles in an ICP is shown to be a likely source of fractionation. A technique for the online detection of stimulated elemental release from neural tissue using magnetic sector ICP-MS is described. Detection limits of 1 mug L-1 or better were found for P, Mn, Fe, Cu, and Zn in a 60 muL injection in a physiological saline matrix.

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Chemistry;Analytical chemistry
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