This study is focused on the pathologies and skeletal abnormalities present among specimens from the Iowa City Collection, narrowed down to four individuals in particular. It compares abnormalities observed on the bones themselves with the written record from the inventory of this collection, identifying which pathology is most common among the specimens, why those pathologies leave their marks in bony tissue, and speculates about the possible origin of this collection before it was loaned to Iowa State from the University of Iowa to become part of the teaching collection for classes in skeletal biology and forensic anthropology.