Mitigation of Airborne PRRSV Transmission with UV Light Treatment: Proof-of-Concept

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Hoff, Steven
Koziel, Jacek
Li, Peiyang
Koziel, Jacek
Zimmerman, Jeffrey
Zhang, Jianqiang
Cheng, Ting-Yu
Yim-Im, Wannarat
Jenks, William
Lee, Myeongseong
Jenks, William
Chen, Baitong
Hoff, Steven
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Food Science and Human NutritionCivil, Construction and Environmental EngineeringChemistryVeterinary Diagnostic and Production Animal MedicineAgricultural and Biosystems EngineeringEnvironmental ScienceToxicology

Proper treatment of infectious air could potentially mitigate the spread of airborne viruses such as porcine reproductive and respiratory syndrome virus (PRRSV). The objective of this research is to test the effectiveness of ultraviolet (UV) in inactivating aerosolized PRRSV, specifically, four UV lamps, UV-A (365 nm, both fluorescent and LED-based), “excimer” UV-C (222 nm), and germicidal UV-C (254 nm), were tested. The two UV-C lamps effectively irradiated fast-moving PRRSV aerosols with short treatment times (<2 s). One-stage and two-stage UV inactivation models estimated the UV doses needed for target percentage (%) reductions on PRRSV titer. UV-C (254 nm) dose needed for 3-log (99.9%) reduction was 0.521 and 0.0943 mJ/cm2, respectively, based on one-stage and two-stage models. An order of magnitude lower UV-C (222 nm) doses were needed for a 3-log reduction, i.e., 0.0882 and 0.048 mJ/cm2, based on one-stage and two-stage models, respectively. However, the cost of 222 nm excimer lamps is still economically prohibitive for scaling-up trials. The UV-A (365 nm) lamps could not reduce PRRSV titers for tested doses up to 4.11 mJ/cm2. Pilot-scale or farm-scale testing of UV-C on PRRSV aerosols simulating barn ventilation rates are recommended based on its effectiveness and reasonable costs comparable to HEPA filtration


This article is published as Li, Peiyang, Jacek A. Koziel, Jeffrey J. Zimmerman, Jianqiang Zhang, Ting-Yu Cheng, Wannarat Yim-Im, William S. Jenks, Myeongseong Lee, Baitong Chen, and Steven J. Hoff. "Mitigation of Airborne PRRSV Transmission with UV Light Treatment: Proof-of-Concept." Agriculture 11, no. 3 (2021): 259. DOI: 10.3390/agriculture11030259. Posted with permission.