Differential surface stress sensor for detection of chemical and biological species

Date
2008-01-01
Authors
Shrotriya, Pranav
Kang, K.
Nilsen-Hamilton, Marit
Shrotriya, Pranav
Nilsen-Hamilton, Marit
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Altmetrics
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Biochemistry, Biophysics and Molecular BiologyMechanical Engineering
Abstract

We report a sensor consisting of two micromachined cantilevers (a sensing/reference pair) that is suitable for detection of chemical and biological species. The sensing strategy involves coating the sensing cantilever with receptors that have high affinities for the analyte. The presence of analyte is detected by determining the differential surface stress associated with its adsorption/absorption to the sensing cantilever. An interferometric technique is utilized to measure the differential bending of the sensing cantilever with respect to reference. Surface stress associated with hybridization of single stranded DNA is measured to demonstrate the unique advantages of the sensor.

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This is an article from Applied Physics Letters 93 (2008): 143107, doi:10.1063/1.2996411. Posted with permission.

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