The objective of this research was to test a pilot-scale air sparged tank reactor (ASTR) and the ASTR in combination with a hydrocyclone (called the pilot-scale ASTR-hydrocyclone system) on two swine manure slurries for struvite-based (MgNH4PO4-6H2O) phosphorus removal and recovery. The pilot-scale ASTR system operated at flow rates of 80 to 115 L/min and was based on the bench-scale design from Shepherd et al. (2007). The ASTR effluent was processed using a hydrocyclone separator for struvite separation and total phosphorus (TP) recovery. The pilot-scale ASTR-hydrocyclone system provided a 92% reduction of dissolved reactive phosphorus (DRP) in manure slurry from a swine finishing facility concrete storage tank and a 91% reduction of DRP in manure slurry collected from a swine finishing facility deep-pit under floor collection system. The pilot-scale ASTR-hydrocyclone system removed 18% of TP in swine manure from a concrete storage tank and 9% to 14% of TP in swine manure slurry from a deep-pit under floor collection system. The low TP recovery was attributed to the hydrocyclones inability to provide effective struvite separation as operated. Full-scale economics and implementation of the tested struvite-based phosphorus removal is discussed. A case study of a typical Iowa deep-pit swine production facility (10,000 head/year) indicated that the annual cost of struvite-based phosphorus removal using this system would be approximately $8.88/finished pig or $0.035/L manure slurry treated ($ 0.134/gal). This cost often exceeds producer's profit margins; this indicates that struvite-based phosphorus removal using this ASTR-hydrocyclone system in swine finisher manure slurries is not currently economically viable.