Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones

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2016_Kraus_TriaceticAcid.pdf (220.17 KB)
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2015-12-01
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Kraus, George
 Wanninayake, Umayangani
 Kraus, George
 Bottoms, Jashaun
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Abstract

At ambient temperature, triacetic acid lactone reacts with amines to produce 4-amino-2-pyrones. If the temperature is raised to 100 °C, 4-hydroxy-2-pyridones are generated.
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This is a manuscript of an article published as Kraus, George A., Umayangani K. Wanninayake, and Jashaun Bottoms. "Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones." Tetrahedron Letters 57, no. 11 (2016): 1293-1295. 10.1016/j.tetlet.2016.02.043. Posted with permission.
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10.1016/j.tetlet.2016.02.043
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https://dr.lib.iastate.edu/handle/20.500.12876/14300
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