Regioselective Diels-Alder reactions. A synthesis of the left-hand portion of CC-1065
Diene 2b reacted regioselectively with dienophiles. Adduct 6 was converted into the left-hand portion of CC-1065 in 10% overall yield.
Reprinted (adapted) with permission from The Journal of Organic Chemistry, 50(2); 283-284. Doi:10.1021/jo00202a029. Copyright 1985 American Chemical Society.