CAR T Cell Therapy

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Date
2019-01-01
Authors
Bonnett, Megan
Major Professor
Jon Mochel
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Altmetrics
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Biomedical Sciences
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Biomedical Sciences
Abstract

With chemotherapy and radiation being the most common forms of cancer treatment, some cancer cells are able to develop resistance and persist in the body. Because of this resistance, there is a need for a new cancer therapy that can attack these persistent cells. CAR T cell therapy utilizes the patient’s own immune system to attack and potentially eliminate these cancer cells. These cells have successfully been used against B cell malignancies, however, not much success has been seen when used against solid tumors. Solid tumors pose many challenges and threats these T cells must overcome in order to produce any anti-tumor effect. Challenges researchers run into include finding a suitable antigen to target, successfully trafficking to and infiltrating the tumor, and overcoming the microenvironment of the tumor. Researchers are continuously trying to figure out ways to overcome these challenges and increase the success of CAR T cell therapy

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