Metal-catalyzed and aryne-mediated multicomponent approaches to heterocycles
Thomas J. Greenbowe
Over the course of the work described in this dissertation, several novel methodologies have been successfully developed and applied to the synthesis of medicinally-relevant heterocycles, including indoles, benzo[b]furans, 1,2-dihydroisoquinolines, 1H-indazoles, and pyrido[1,2-a]indoles. In these methods, well-studied transition metal-catalyzed processes and newly discovered aryne-mediated processes have been found applicable and efficient when applied to the synthesis of a variety of heterocycles. Most of these processes have also been transformed into multicomponent processes.