Influence of food on the bioavailability of a docosahexaenoic acid supplement

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2012-01-01
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Kratzer, Stephanie
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Christina Campbell
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Food Science and Human Nutrition
Abstract

The purpose of this project was to observe whether consuming a DHA supplement with or without a meal influenced the bioavailability of the DHA supplement. Healthy males (n = 109) aged 18-45 years were randomized to 4 study groups that included 200 mg/d DHA consumed with a meal, 200 mg/d DHA consumed fasted, 1000 mg/d DHA consumed with a meal or 1000 mg/d DHA consumed in a fasted state over 8 weeks. Fasted venous blood samples were collected pre- and post-DHA supplementation for analysis of plasma phospholipid (PL) fatty acid analysis. Plasma PL DHA increased significantly in all groups (P < 0.0001). The increase in DHA was significantly different between all dose groups (200 mg versus 1000 mg; P < 0.0001). There were no differences between the meal or fasted groups. Thus, consuming a DHA supplement with a meal did not increase the bioavailability of the DHA supplement.

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Sun Jan 01 00:00:00 UTC 2012