Dynamics of Autophagosome Formation

Date
2018-01-01
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Soto-Burgos, Junmarie
Bassham, Diane
Zhuang, Xiaohong
Jiang, Liwen
Bassham, Diane
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Genetics, Development and Cell Biology
Abstract

Autophagy, literally defined as “self-eating,” functions as a degradation process by recycling cytoplasmic contents under stress conditions or during development. Upon activation of autophagy, a membrane structure known as a phagophore forms and expands, finally closing to form a double-membrane vesicle called an autophagosome (Fig. 1; Lamb et al., 2013; Yin et al., 2016). The completed autophagosome, which contains the autophagic cargo, is delivered to the vacuole (plants and yeast) or lysosome (animals). The outer membrane fuses with the vacuolar/lysosomal membrane, and the inner membrane and contents are released into the vacuole/lysosome as an autophagic body and are degraded by hydrolases. The breakdown products are transported back into the cytoplasm for reuse by the cell (Yang and Bassham, 2015).

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This article is published as Soto-Burgos J, Zhuang X, Jiang L, Bassham DC. Dynamics of Autophagosome Formation. Plant physiology. 2018; 176:219-229. doi: 10.1104/pp.17.01236. Copyright American Society of Plant Biologists. Posted with permission.

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