Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects
Date
2015
Authors
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
© The Royal Society of Chemistry 2015
Authors
Person
Research Projects
Organizational Units
Organizational Unit
Organizational Unit
Journal Issue
Is Version Of
Versions
Series
Department
Biochemistry, Biophysics and Molecular BiologyAmes Laboratory
Abstract
Plant metabolomics has matured and modern plant metabolomics has accelerated gene discoveries and the elucidation of a variety of plant natural product biosynthetic pathways. This review highlights specific examples of the discovery and characterization of novel genes and enzymes associated with the biosynthesis of natural products such as flavonoids, glucosinolates, terpenoids, and alkaloids. Additional examples of the integration of metabolomics with genome-based functional characterizations of plant natural products that are important to modern pharmaceutical technology are also reviewed. This article also provides a substantial review of recent technical advances in mass spectrometry imaging,
nuclear magnetic resonance imaging, integrated LC-MS-SPE-NMR for metabolite identifications, and x-ray crystallography of microgram quantities for structural determinations. The review closes with a discussion on the future prospects of
metabolomics related to crop species and herbal medicine.
Comments
This is a manuscript of an article published as Sumner, Lloyd W., Zhentian Lei, Basil J. Nikolau, and Kazuki Saito. "Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects." Natural product reports 32, no. 2 (2015): 212-229. doi:10.1039/C4NP00072B. Posted with permission.