Multidrug Resistant and toxigenic Clostridium difficile isolated from commercial swine and humans
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The SafePork conference series began in 1996 to bring together international researchers, industry, and government agencies to discuss current Salmonella research and identify research needs pertaining to both pig and pork production. In subsequent years topics of research presented at these conferences expanded to include other chemical and biological hazards to pig and pork production.
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Abstract
This study was conducted to compare C. difficile population in commercial swine with those causing C. difficile associated diarrhea (CDAD) cases in humans. Fecal samples were collected from sows (eight per fam1) and piglets (30 per fam1) in eight farms in North Carolina (n=5) and Ohio (n=3) representing a total of 68 sows and 251 piglets. In addition, 33 C. difficile isolates were collected from CDAD cases in humans from the NC region. C. difficile isolates were tested for their susceptibility to a panel of six antimicrobials. PCR was used to detect genes coding for enterotoxin A (tcdA), cytotoxin B (tcdB) and the binary toxin (COT). We detected significantly higher piglet prevalence in Ohio (87.5%) than North Carolina (64%) (P < 0.001).