Pharmacokinetics of meloxicam in mature swine after intravenous andoral administration

Date
2015-06-01
Authors
Karriker, Locke
Butters-Johnson, Anna
Pairis-Garcia, Monique
Johnson, Anna
Stalder, Kenneth
Kukanich, Butch
Wulf, Larry
Millman, Suzanne
Stalder, Kenneth
Karriker, Locke
Coetzee, Johann
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Research Projects
Organizational Units
Animal Science
Organizational Unit
Journal Issue
Series
Department
Animal Science
Abstract

The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (IV) and oral (PO) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3± 65.68 kg) were administered an IV or PO dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX) after PO administration was 1070 ng/ml (645-1749 ng/ml). TMAX was recorded at 2.40 hour (0.50-12.00 hours) after PO administration. Half-life (T ½ λz) for IV and PO administration was 6.15 hours (4.39-7.79 hours) and 6.83 hours (5.18-9.63 hours) respectively. The bioavailability (F) for PO administration was 87% (39-351%). The results of the present study suggest that meloxicam is well absorbed after oral administration.

Comments

This is a manuscript of an article from Journal of Veterinary Pharmacology and Therapeutics 38 (2015): 265, doi:10.11 11/jvp.12170. Posted with permission.

Description
Keywords
Citation
DOI
Collections