Evaluation of the IgA response to attenuated-live oral Lawsonia intracellularis vaccine

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Sattler, Kendall
Billing, Melissa Farber
Magtoto, Ronaldo L.
Mora-Diaz, Juan Carlos
Leite, Fernando
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American Association of Swine Veterinarians
Giménez-Lirola, Luis
Associate Professor
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Veterinary Diagnostic and Production Animal Medicine
The mission of VDPAM is to educate current and future food animal veterinarians, population medicine scientists and stakeholders by increasing our understanding of issues that impact the health, productivity and well-being of food and fiber producing animals; developing innovative solutions for animal health and food safety; and providing the highest quality, most comprehensive clinical practice and diagnostic services. Our department is made up of highly trained specialists who span a wide range of veterinary disciplines and species interests. We have faculty of all ranks with expertise in diagnostics, medicine, surgery, pathology, microbiology, epidemiology, public health, and production medicine. Most have earned certification from specialty boards. Dozens of additional scientists and laboratory technicians support the research and service components of our department.
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Porcine proliferative enteropathy (PPE), commonly referred to as ileitis, is an infectious enteric disease leading to decreased production performance of growing pigs. The etiological agent of this disease, Lawsonia intracellularis, is a Gram-negative bacterium found in swine worldwide.1 An avirulent live oral vaccine, Enterisol® Ileitis (Boehringer Ingelheim Animal Health USA Inc.), is currently available to immunize pigs to prevent this disease and subsequent economic loss from mortality, decreased feed efficiency, and poor weight gain.2 Recent research has found that anti-L intracellularis immunoglobin A (IgA) and immunoglobulin G (IgG) can be observed in oral fluids and serum following experimental L intracellularis challenge.3 Given the role that IgA plays in protecting the intestine and mucosal surfaces, we elected to evaluate IgA.4,5 The objective of this study was to investigate if IgA against L intracellularis could be detected in serum and in oral fluids following vaccination with Enterisol® Ileitis.
This proceeding is published as Sattler, Kendall, Melissa Farber Billing, Luis Gimenez-Lirola, Ronaldo L. Magtoto, Juan Carlos Mora-Diaz, and Fernando Leite. "Evaluation of the IgA response to attenuated-live oral Lawsonia intracellularis vaccine." doi: https://doi.org/10.54846/am2023/23. Posted with permission.